Managing Locations (formerly referred to as Geography) may not be necessary if you imported the default ecommerce information into the database. Otherwise, you'll need to enter information about the countries and regions/states you'll be selling/shipping to. The e-Commerce system uses the country/region codes to determine many aspects of shipping and taxing which are essential to properly processing orders.
Parent Help Topic
e-Commerce Store Setup
There are some settings you must establish for your e-Commerce store to work....